DNA methylation

DNA methylation is an important epigenetic modification which regulates a number of biological processes.

DNA甲基化作为一种重要的表观遗传修饰,调节着机体许多生物学过程.

The changes of epigenetics such as DNA methylation and histone modification can regulate the expression of genes and play an important role in the development of tumors.

表遗传学改变，如DNA甲基化和组蛋白修饰改变可以调节基因的表达，在肿瘤的发生和发展中可能起关键作用。

Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.

活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。

Alteration of plasma folic acid and DNA methylation in human gastric cancer

人胃癌血浆叶酸与DNA甲基化的改变

DNA methylation is often interact with histone modification to regulate gene expression.

DNA甲基化往往与组蛋白修饰相互作用共同调控基因的表达。

The study on the cellular and molecular mechanism of the citrus mutated characteristics is particularly introduced. The research on citrus bud mutation is focusing on retrotransposon insertion, DNA methylation and the difference of gene structure and expression.

阐述了部分柑橘芽变性状形成的细胞学机理和分子机理，指出目前对芽变的研究主要集中在反转录转座子的插入、DNA甲基化、基因结构和表达差异等方面。

The Effect of DNA Methylation and Histone Modification on the Development of Cloned Embryos

DNA甲基化与组蛋白修饰对克隆胚发育的影响

Histone deacetylase inhibitor ( HDACi) has been shown to demethylate mammalian genome, which further strengthens the concept that DNA methylation and histone modifications interact in regulation of gene expression.

已有报道证实组蛋白去乙酰化酶抑制剂（HDACi）可以引起哺乳动物基因组的去甲基化，这支持了DNA甲基化和组蛋白修饰可以相互作用调节基因的表达的观点。

Focus on the bioinformatics analysis of DNA methylation.

主要研究DNA甲基化的生物信息学分析.

Epigenetic modification includes DNA methylation and histone modifications.

表观遗传修饰主要有DNA甲基化和以组蛋白修饰为特征的染色质重塑。

The two primary changes of epigenetic mechanism are the DNA methylation and the histone modification.

表观遗传改变的两个最主要机制就是DNA甲基化和组蛋白修饰。

Alterations in DNA methylation, an important regulator of gene transcription, lead to cancer.

对调节基因转录起重要作用的DNA甲基化的异常将导致癌症的发生.

Although researches in this area have been reported, but DNA methylation in the hybrid variations of inter-generational studys are rare.

虽然这方面的研究报道已有很多，但DNA甲基化在杂交世代间的变异规律的研究并不多见。

Study on aberrant DNA methylation of dopamine D4 receptor gene in acute myeloid leukemia

白血病细胞多巴胺受体基因甲基化研究

The results demonstrate DNA methylation events occur frequently in navel oranges; methylation patterns vary among the cultivars, and the external cytosine methylation of the CCGG sequence ( 15.0%) is more than internal one ( 4.7%).

结果显示DNA甲基化在脐橙中发生频繁，且品种之间的甲基化模式存在较大差异，脐橙CCGG序列中胞嘧啶甲基化外部（15.0%）多于内部（4.7%）。

Epigenetic mechanisms, including DNA methylation, histone modification and chromatin remodeling, have been demonstrated to be involved in the development of SLE.

表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。

Non-DNA sequence variations, such as DNA methylation and histone modification, can also change biological traits such as plant height, flowering time, resistance and yield.

非DNA序列变异，如DNA甲基化、组蛋白修饰等亦可改变生物性状，包括重要农艺性状如株高、花期、抗性、产量等，并可稳定遗传。

DNA methylation and its aberrance play an important role in the human development and tumorigenesis.

DNA的甲基化及甲基化异常在人体发育和肿瘤的发生中起着至关重要的作用.

Comparison of DNA Methylation Levels in Different Organs and Shoot Apices at Different Development Stages of Non-heading Chinese Cabbage

白菜不同器官及不同生育期茎尖甲基化水平比较

Epigenetic variation plays an important role in plant growth and development, including DNA methylation, histone modification, chromosome remodeling, and RNA interference and so on.

表观遗传变异对于植物的生长发育起着重要作用，主要包括DNA甲基化、组蛋白修饰、染色体重塑和RNA干涉等。

Aberrant DNA Methylation and Histone Modification in Tumor

肿瘤DNA异常甲基化与组蛋白修饰

DNA methylation is the only known covalent modification of DNA molecule. It is accomplished by transfer of the methyl group from S-adenosyl methionine to 5 position of the purine ring of cytosine.

DNA甲基化（DNA Methylation）是目前已知的唯一天然的DNA共价修饰方式，由DNA转移酶催化，将S-腺苷甲硫氨酸上的甲基转移到胞嘧啶嘌呤环的第五位碳原子上。

In the paternal or maternal alcohol exposure during pregnancy, parents with alcohol intake during pregnancy may damage DNA methylation and histone modifications of pre-implantation embryo. We provide prevent the harm of alcohol to the fetus.

在父性、母性孕期酒精暴露研究中，怀孕期间酒精摄入对植入前胚胎DNA甲基化及组蛋白修饰可能造成损害的差异，也为我们预防酒精对胎儿的伤害提供借鉴的作用。

DNA methylation is a common event in malignances and implicated in tumor initiation and progression.

DNA甲基化是恶性肿瘤普遍存在的分子生物学改变,与肿瘤的发生和发展密切相关.

Epigenetic mechanisms include DNA methylation, histone modifications such as acetylation and methylation, and control of mRNA expression by non-coding RNAs.

表观遗传学包括DNA甲基化、组蛋白修饰以及由非编码RNA调控的mRNA表达等。

Epigenetics refers to gene expression changes which DNA sequence will not changed, the main contents of epigenetic mechanism is that DNA methylation and histone modification.

表观遗传学指不发生DNA序列改变的基因表达改变，DNA甲基化和组蛋白修饰是其中的两个主要内容。

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many eukaryotes that has important implications for normal biology and disease.

DNA中胞嘧啶碱基的甲基化在很多真核细胞中提供了一层表观控制，它对于正常生物学和疾病有着重要的意义。

4.7%-15.0% DNA methylation events were detected in the CCGG sequence of navel orange genomes.

结果表明，脐橙基因组的CCGG序列中检测到4.7%～15.0%的DNA发生甲基化；

The analysis of DNA methylation in plasma applicate to noninvasive prenatal diagnosis.

血浆DNA甲基化的分析进一步应用于无创性产前诊断具有可行性.

Researchers looked for-and found-a chemical change called DNA methylation in healthy tissue adjacent to breast tumors.

研究者寻找并发现了靠近肿瘤组织的健康组织中有“DNA甲基化”这种化学改变.